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The formal Tamil translation for "How are you?" in a professional email context is: **"நீங்கள் எப்படி இருக்கிறீர்கள்?"** *(Nīṅkaḷ eppaṭi irukkiṟīrkaḷ?)* This is the polite and respectful form suitable for formal communication. For additional context, you could also use: **"உங்கள் நலம் எப்படி உள்ளது?"** *(Uṅkaḷ nalam eppaṭi uḷḷadhu?)* *(Literally: "How is your well-being?")* Both are appropriate for professional correspondence.