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DeCAF Pearl

DeCAF-Pearl is Genesis Molecular AI’s flow-map distilled version of its Pearl cofolding model for all-atom biomolecular structure generation. It is designed to accelerate protein-ligand cofolding by learning larger jumps through the denoising trajectory instead of requiring many small diffusion steps. Genesis reports that DeCAF-Pearl makes about 20x fewer model calls during diffusion sampling and delivers about a 5x full inference speedup while retaining most of the teacher model’s quality. Its main uses are high-throughput virtual screening, faster protein-ligand complex prediction, and scalable synthetic data generation for downstream molecular-design models.
New 3d Gen 1
Released: June 10, 2026

Overview

DeCAF-Pearl is Genesis Molecular AI’s distilled all-atom cofolding model for faster protein-ligand structure prediction and molecular-design screening.

About Genesis Molecular AI

Genesis Therapeutics is a biotechnology company that utilizes AI to discover novel treatments for severe medical conditions.

Industry: Biotechnology
Company Size: 11-50
Location: Burlingame, california, US
Website: genesis.ml
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Tools using DeCAF Pearl

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Last updated: June 11, 2026
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