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Mini toolsESMFold2
ESMFold2 is Biohub’s protein-structure prediction model in the ESM protein biology system. It predicts protein structure from amino acid sequence and was used to expand ESM Atlas into a large map of protein biology, with reporting describing 6.8 billion proteins and 1.1 billion predicted structures. Nature describes the new open-source atlas as generated by ESMFold2 and says it vastly increases the known protein universe. Biohub frames the overall release as a “world model of protein biology” for protein prediction, design, discovery, function mapping, and therapeutic research, though therapeutic use would still require downstream validation and safety testing.
New
Multimodal
Gen 3
Overview
ESMFold2 is Biohub’s open protein-structure prediction model for predicting 3D protein structures from amino acid sequences and powering large-scale ESM Atlas structure mapping.
About Chan Zuckerberg Biohub
Chan Zuckerberg Biohub is a 501(c)(3) nonprofit biomedical research organization combining frontier AI and frontier biology to understand and cure disease. It operates research hubs in San Francisco, Chicago, and New York, and develops open AI tools including the ESM family of protein language models (ESMFold2, ESMC, ESM Atlas), made freely available to the global scientific community.
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Last updated: June 2, 2026
